A Fabrication Method for Integrating Electrodes in Nanofluidic Channels

نویسندگان

  • T. M. Wynne
  • X. T. Huang
  • S. Pennathur
چکیده

Nanofluidic channels are unique bioanalytical tools that can separate, detect, analyze and concentrate biomolecules. Embedding electodes in such systems increases the functionality by allowing for unique flow control, label-free sensing, and concentration enhancement. In this work, we describe the fabrication process of nanofluidic channels with integrated electrodes, as well as the characterization of such channels. The key aspects of our surface-micromachined process is the use of a side-release etch to overcome diffusion limited etching of long thin channels, and a low-temperature process (<300 C), to allow for for the integration of addressable electrodes for a variety of bioanalytical applications.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Wafer-scale integration of sacrificial nanofluidic chips for detecting and manipulating single DNA molecules

Wafer-scale fabrication of complex nanofluidic systems with integrated electronics is essential to realizing ubiquitous, compact, reliable, high-sensitivity and low-cost biomolecular sensors. Here we report a scalable fabrication strategy capable of producing nanofluidic chips with complex designs and down to single-digit nanometre dimensions over 200 mm wafer scale. Compatible with semiconduct...

متن کامل

Nanofluidic channels of arbitrary shapes fabricated by tip-based nanofabrication.

Nanofluidic channels have promising applications in biomolecule manipulation and sensing. While several different methods of fabrication have been demonstrated for nanofluidic channels, a rapid, low-cost fabrication method that can fabricate arbitrary shapes of nanofluidic channels is still in demand. Here, we report a tip-based nanofabrication (TBN) method for fabricating nanofluidic channels ...

متن کامل

Site-specific nanopatterning of functional metallic and molecular arbitrary features in nanofluidic channels.

We established a versatile method for site-specific nanopatterning of functional metallic and molecular arbitrary features in glass nanofluidic channels, with well-controlled feature sizes ranging from tens to hundreds of nanometers and precisely controlled placements in the range of several tens of nanometers. With the method, we achieved the fabrication of quasi-0D, quasi-1D, 2D, and 3D gold ...

متن کامل

Fabrication and electroosmotic flow measurements in micro- and nanofluidic channels

An easy method for fabricating microand nanofluidic channels, entirely made of a thermally grown silicon dioxide is presented. The nanochannels are up to 1-mm long and have widths and heights down to 200 nm, whereas the microfluidic channels are 20-lm wide and 4.8-lm high. The nanochannels are created at the interface of two silicon wafers. Their fabrication is based on the expansion of growing...

متن کامل

Fabrication and characterization of 20 nm planar nanofluidic channels by glass-glass and glass-silicon bonding.

We have characterized glass-glass and glass-Si bonding processes for the fabrication of wide, shallow nanofluidic channels with depths down to the nanometer scale. Nanochannels on glass or Si substrate are formed by reactive ion etching or a wet etching process, and are sealed with another flat substrate either by glass-glass fusion bonding (550 degrees C) or an anodic bonding process. We demon...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2011